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Most cases of liver cancer and several cases of breast, colorectal, gastric, pancreatic and ovarian cancer showed moderate to strong cytoplasmic and membranous immunoreactivity. The remaining cancers were mainly negative.
Cancer tissues showed weak to moderate cytoplasmic immunoreactivity. Few cases of prostate cancers showed strong staining. Lymphomas and skin cancers were negative.
GENE INFORMATION
Gene name
USP24 (HGNC Symbol)
Synonyms
KIAA1057
Description
Ubiquitin specific peptidase 24 (HGNC Symbol)
Entrez gene summary
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process]
