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USP24

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GENERAL INFORMATION

Gene name

 USP24

Gene description

 Ubiquitin specific peptidase 24

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 3 antibodies.
HPA026723 , HPA028428 , HPA067124
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA026723 A-431 Nucleoplasm
HPA026723 U-2 OS Nucleoplasm
HPA026723 U-251 MG Nucleoplasm
HPA028428 A-431 Nucleoplasm
HPA028428 U-2 OS Nucleoplasm
Cytosol
HPA028428 U-251 MG Nucleoplasm
HPA067124 SK-MEL-30 Nucleoplasm
HPA067124 U-2 OS Nucleoplasm
Actin filaments
HPA067124 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 USP24 (HGNC Symbol)

Synonyms

 KIAA1057

Description

 Ubiquitin specific peptidase 24 (HGNC Symbol)

Entrez gene summary

 Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

Chromosome

 1

Cytoband

 p32.3

Chromosome location (bp)

 55066359 - 55215113

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162402 (version 83.38)

Entrez gene

 23358

UniProt

 Q9UPU5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPU5

Antibodypedia

 USP24 antibodies

PROTEIN BROWSER
USP24-001
USP24-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP24-001
ENSP00000294383
ENST00000294383
Q9UPU5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 24
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 2620 aa
294.4 kDa 		No 0
USP24-005
ENSP00000489026
ENST00000484447
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 150 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.