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Weak to moderate cytoplasmic positivity was displayed in most malignant cells. Few cases of squamous cell carcinomas showed strong immunoreactivity. Lymphomas were negative.
Weak to moderate cytoplasmic positivity was observed in most malignant cells. Few cases of colorectal cancers showed strong staining. Hepatocellular carcinomas and lymphomas were weakly stained or negative.
Malignant cells were in general weakly stained or negative. A few cases of malignant melanoma, testicular and liver cancer showed moderate cytoplasmic positivity.
GENE INFORMATION
Gene name
DNAJB4 (HGNC Symbol)
Synonyms
HLJ1
Description
DnaJ (Hsp40) homolog, subfamily B, member 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
