Cell atlas - DNAJB4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DNAJB4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	DNAJB4
Gene description	DnaJ (Hsp40) homolog, subfamily B, member 4
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.
RNA cell category	Cell line enhanced (LHCN-M2, HUVEC TERT2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Plasma membrane (validated), Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA028383 , HPA028385
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (LHCN-M2, HUVEC TERT2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

Main location

Nucleoplasm (validated)

Additional location

Plasma membrane (validated), Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA028383	A-431	Nucleoplasm
		Plasma membrane
		Cytosol
HPA028383	U-251 MG	Nucleoplasm
HPA028383	U-251 MG	Cytosol
HPA028385	A-431	Nucleoplasm
		Plasma membrane
		Cytosol
HPA028385	U-2 OS	Nucleoplasm
HPA028385	U-2 OS	Cytosol
HPA028385	U-251 MG	Nucleoplasm
HPA028385	U-251 MG	Cytosol

GENE INFORMATION
Gene name	DNAJB4 (HGNC Symbol)
Synonyms	HLJ1
Description	DnaJ (Hsp40) homolog, subfamily B, member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	77979175 - 78017964
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162616 (version 83.38)
Entrez gene	11080
UniProt	Q9UDY4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UDY4
Antibodypedia	DNAJB4 antibodies

PROTEIN BROWSER

DNAJB4-001	DNAJB4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAJB4-001 ENSP00000359799 ENST00000370763	Q9UDY4 [Direct mapping] DnaJ homolog subfamily B member 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0006986 [response to unfolded protein] GO:0009408 [response to heat] GO:0051082 [unfolded protein binding] GO:0051087 [chaperone binding] GO:0070062 [extracellular exosome] Show all	337 aa 37.8 kDa	No	0
DNAJB4-003 ENSP00000399494 ENST00000426517	C9JUL4 [Direct mapping] DnaJ homolog subfamily B member 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	172 aa 19.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.