Cell atlas - HFM1 - The Human Protein Atlas

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HFM1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	HFM1
Gene description	HFM1, ATP-dependent DNA helicase homolog
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus & vesicles.
RNA cell category	Cell line enhanced (AF22, AN3-CA, K-562, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (uncertain), Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 2 antibodies. HPA035036 , HPA035557
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, AN3-CA, K-562, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus & vesicles.

Main location

Golgi apparatus (uncertain), Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA035036	AF22	Golgi apparatus
HPA035036	U-2 OS	Golgi apparatus
HPA035036	U-2 OS	Vesicles
HPA035036	U-251 MG	Golgi apparatus
HPA035036	U-251 MG	Vesicles
HPA035557	AF22	Vesicles
HPA035557	U-2 OS	Vesicles
HPA035557	U-251 MG	Vesicles

GENE INFORMATION
Gene name	HFM1 (HGNC Symbol)
Synonyms	FLJ36760, FLJ39011, MER3, SEC63D1
Description	HFM1, ATP-dependent DNA helicase homolog (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014]
Chromosome	1
Cytoband	p22.2
Chromosome location (bp)	91260766 - 91404869
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162669 (version 83.38)
Entrez gene	164045
UniProt	A2PYH4 (UniProt - Evidence at protein level)
neXtProt	NX_A2PYH4
Antibodypedia	HFM1 antibodies

PROTEIN BROWSER

HFM1-002	HFM1-005	HFM1-006	HFM1-007	HFM1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HFM1-002 ENSP00000359454 ENST00000370425	A2PYH4 [Direct mapping] Probable ATP-dependent DNA helicase HFM1 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0000712 [resolution of meiotic recombination intermediates] GO:0003676 [nucleic acid binding] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	1435 aa 162.6 kDa	No	0
HFM1-005 ENSP00000397369 ENST00000448819	C9JA44 [Direct mapping] Probable ATP-dependent DNA helicase HFM1 Show all	Predicted intracellular proteins Show all		151 aa 17.1 kDa	No	0
HFM1-006 ENSP00000388900 ENST00000427444	C9JQ07 [Direct mapping] Probable ATP-dependent DNA helicase HFM1 Show all	Predicted intracellular proteins Show all		196 aa 22.2 kDa	No	0
HFM1-007 ENSP00000409827 ENST00000455133	C9JQP7 [Direct mapping] Probable ATP-dependent DNA helicase HFM1 Show all	Predicted intracellular proteins Show all		138 aa 15.9 kDa	No	0
HFM1-008 ENSP00000387661 ENST00000430465	H0Y3X7 [Direct mapping] Probable ATP-dependent DNA helicase HFM1 Show all	Predicted intracellular proteins Show all		625 aa 70.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.