Expression of CADM3 in cancer - Summary

CANCER ATLAS

Gene description

Cell adhesion molecule 3

Protein class

Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA002981	CAB025746

GENE INFORMATION
Gene name	CADM3 (HGNC Symbol)
Synonyms	BIgR, FLJ10698, IGSF4B, Necl-1, NECL1, SynCAM3, TSLL1
Description	Cell adhesion molecule 3 (HGNC Symbol)
Entrez gene summary	IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	159171609 - 159203313
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162706 (version 83.38)
Entrez gene	57863
UniProt	Q8N126 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N126
Antibodypedia	CADM3 antibodies

PROTEIN BROWSER

CADM3-001	CADM3-002	CADM3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CADM3-001 ENSP00000357107 ENST00000368125	Q8N126 [Direct mapping] Cell adhesion molecule 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0045216 [cell-cell junction organization] GO:0050839 [cell adhesion molecule binding] Show all	398 aa 43.3 kDa	Yes	1
CADM3-002 ENSP00000357106 ENST00000368124	Q8N126 [Direct mapping] Cell adhesion molecule 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0008104 [protein localization] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0045216 [cell-cell junction organization] GO:0050839 [cell adhesion molecule binding] Show all	432 aa 47 kDa	Yes	1
CADM3-004 ENSP00000387802 ENST00000416746	A0A0C4DG09 [Direct mapping] Cell adhesion molecule 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	234 aa 25.7 kDa	Yes	0