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CADM3

GENERAL INFORMATION

Gene name

 CADM3

Gene description

 Cell adhesion molecule 3

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, placenta)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Group enriched (cerebellum, brain, caudate, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 High expression in neuropil, peripheral nerves and cells in placental stroma.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA002981 , CAB025746
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, brain, caudate, hippocampus)

GENE INFORMATION

Gene name

 CADM3 (HGNC Symbol)

Synonyms

 BIgR, FLJ10698, IGSF4B, Necl-1, NECL1, SynCAM3, TSLL1

Description

 Cell adhesion molecule 3 (HGNC Symbol)

Entrez gene summary

 IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008]

Chromosome

 1

Cytoband

 q23.2

Chromosome location (bp)

 159171609 - 159203313

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162706 (version 83.38)

Entrez gene

 57863

UniProt

 Q8N126 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N126

Antibodypedia

 CADM3 antibodies

PROTEIN BROWSER
CADM3-001
CADM3-002
CADM3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CADM3-001
ENSP00000357107
ENST00000368125
Q8N126 [Direct mapping]
Cell adhesion molecule 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
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 398 aa
43.3 kDa 		Yes 1
CADM3-002
ENSP00000357106
ENST00000368124
Q8N126 [Direct mapping]
Cell adhesion molecule 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0008104 [protein localization]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042803 [protein homodimerization activity]
GO:0045216 [cell-cell junction organization]
GO:0050839 [cell adhesion molecule binding]
Show all
 432 aa
47 kDa 		Yes 1
CADM3-004
ENSP00000387802
ENST00000416746
A0A0C4DG09 [Direct mapping]
Cell adhesion molecule 3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 234 aa
25.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.