Cell atlas - FCMR - The Human Protein Atlas

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FCMR

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Focal adhesion sites
	Nucleus

Human cell
	Actin Filaments
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FCMR
Gene description	Fc fragment of IgM receptor
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the focal adhesion sites. In addition localized to the nucleus & cytosol.
RNA cell category	Group enriched (RPMI-8226, U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Focal adhesion sites (approved)
Additional location	In addition localized to the Nucleus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003910
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPMI-8226, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the focal adhesion sites. In addition localized to the nucleus & cytosol.

Main location

Focal adhesion sites (approved)

Additional location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003910	A-431	Focal adhesion sites
	HPA003910	A-431	Cytosol
	HPA003910	U-2 OS	Nucleus
			Focal adhesion sites
			Cytosol
	HPA003910	U-251 MG	Focal adhesion sites
	HPA003910	U-251 MG	Cytosol

GENE INFORMATION
Gene name	FCMR (HGNC Symbol)
Synonyms	FAIM3, TOSO
Description	Fc fragment of IgM receptor (HGNC Symbol)
Entrez gene summary	Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	206904386 - 206923247
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162894 (version 83.38)
Entrez gene	9214
UniProt	O60667 (UniProt - Evidence at protein level)
neXtProt	NX_O60667
Antibodypedia	FCMR antibodies

PROTEIN BROWSER

FCMR-001	FCMR-004	FCMR-005	FCMR-006	FCMR-007	FCMR-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCMR-001 ENSP00000356058 ENST00000367091	O60667 [Direct mapping] Fas apoptotic inhibitory molecule 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002376 [immune system process] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006968 [cellular defense response] GO:0016021 [integral component of membrane] GO:0043066 [negative regulation of apoptotic process] Show all	390 aa 43.1 kDa	Yes	1
FCMR-004 ENSP00000404136 ENST00000442471	O60667 [Direct mapping] Fas apoptotic inhibitory molecule 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002376 [immune system process] GO:0005576 [extracellular region] GO:0006968 [cellular defense response] GO:0016021 [integral component of membrane] GO:0043066 [negative regulation of apoptotic process] Show all	278 aa 31 kDa	No	1
FCMR-005 ENSP00000436316 ENST00000530505	E9PPV1 [Direct mapping] Protein FCMR Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	141 aa 15.2 kDa	No	0
FCMR-006 ENSP00000432936 ENST00000525793	E9PN59 [Direct mapping] Protein FCMR Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	151 aa 17.2 kDa	Yes	0
FCMR-007 ENSP00000437331 ENST00000529560	E9PMT7 [Direct mapping] Protein FCMR Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	147 aa 16.7 kDa	Yes	0
FCMR-010 ENSP00000485739 ENST00000628511	O60667 [Direct mapping] Fas apoptotic inhibitory molecule 3 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002376 [immune system process] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006968 [cellular defense response] GO:0016021 [integral component of membrane] GO:0043066 [negative regulation of apoptotic process] Show all	306 aa 33.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.