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A few cases of ovarian, liver, testicular, renal and endometrial cancers showed weak to moderate cytoplasmic and/or nuclear positivity. Remaining cancer tissues were negative.
A majority of cancer tissues showed weak to moderate nuclear and cytoplasmic positivity. Several cases of lymphomas were negative.
GENE INFORMATION
Gene name
PUS10 (HGNC Symbol)
Synonyms
CCDC139, FLJ32312
Description
Pseudouridylate synthase 10 (HGNC Symbol)
Entrez gene summary
Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by OMIM, May 2009]
