Cell atlas - PUS10 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PUS10
Gene description	Pseudouridylate synthase 10
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria, nuclear bodies & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear bodies (approved), Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049582
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria, nuclear bodies & nucleoplasm.

Main location

Nucleoplasm (approved), Nuclear bodies (approved), Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA049582	A-431	Nucleoplasm
		Nuclear bodies
		Mitochondria
HPA049582	HeLa	Nucleoplasm
		Nuclear bodies
		Mitochondria
HPA049582	U-2 OS	Nucleoplasm
HPA049582	U-2 OS	Mitochondria	Intensity

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000020280 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049582	NIH 3T3	Mitochondria

GENE INFORMATION
Gene name	PUS10 (HGNC Symbol)
Synonyms	CCDC139, FLJ32312
Description	Pseudouridylate synthase 10 (HGNC Symbol)
Entrez gene summary	Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by OMIM, May 2009]
Chromosome	2
Cytoband
Chromosome location (bp)	60940222 - 61018259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162927 (version 83.38)
Entrez gene	150962
UniProt	Q3MIT2 (UniProt - Evidence at protein level)
neXtProt	NX_Q3MIT2
Antibodypedia	PUS10 antibodies

PROTEIN BROWSER

PUS10-001	PUS10-002	PUS10-003	PUS10-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PUS10-001 ENSP00000326003 ENST00000316752	Q3MIT2 [Direct mapping] Putative tRNA pseudouridine synthase Pus10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	529 aa 60.2 kDa	No	0
PUS10-002 ENSP00000381651 ENST00000398658	A8MUL8 [Direct mapping] Putative tRNA pseudouridine synthase Pus10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 7.3 kDa	No	0
PUS10-003 ENSP00000402185 ENST00000421319	C9JNL8 [Direct mapping] Putative tRNA pseudouridine synthase Pus10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 13.6 kDa	No	0
PUS10-004 ENSP00000386074 ENST00000407787	Q3MIT2 [Direct mapping] Putative tRNA pseudouridine synthase Pus10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001522 [pseudouridine synthesis] GO:0003723 [RNA binding] GO:0008033 [tRNA processing] GO:0009451 [RNA modification] GO:0009982 [pseudouridine synthase activity] Show all	529 aa 60.2 kDa	No	0