Cell atlas - VSNL1 - The Human Protein Atlas

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VSNL1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	VSNL1
Gene description	Visinin-like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (HaCaT, Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA053808
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053808	A-431	No staining
	HPA053808	Hep G2	Cytosol
	HPA053808	U-2 OS	No staining

GENE INFORMATION
Gene name	VSNL1 (HGNC Symbol)
Synonyms	HLP3, HPCAL3, HUVISL1, VILIP, VILIP-1
Description	Visinin-like 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p24.2
Chromosome location (bp)	17539126 - 17657018
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163032 (version 83.38)
Entrez gene	7447
UniProt	P62760 (UniProt - Evidence at protein level)
neXtProt	NX_P62760
Antibodypedia	VSNL1 antibodies

PROTEIN BROWSER

VSNL1-001	VSNL1-002	VSNL1-003	VSNL1-004	VSNL1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VSNL1-001 ENSP00000295156 ENST00000295156	P62760 [Direct mapping] Visinin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	191 aa 22.1 kDa	No	0
VSNL1-002 ENSP00000384719 ENST00000406397	P62760 [Direct mapping] Visinin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0045921 [positive regulation of exocytosis] GO:0046676 [negative regulation of insulin secretion] Show all	191 aa 22.1 kDa	No	0
VSNL1-003 ENSP00000384014 ENST00000404666	P62760 [Direct mapping] Visinin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	191 aa 22.1 kDa	No	0
VSNL1-004 ENSP00000405511 ENST00000457525	E7ER47 [Direct mapping] Visinin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	118 aa 13.8 kDa	No	0
VSNL1-005 ENSP00000390124 ENST00000451533	E9PE24 [Direct mapping] Visinin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	104 aa 12.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.