Fields »
ABOUT
HELP
BLOG
EN1

CANCER ATLAS

Gene description

 Engrailed homeobox 1

Protein class

 Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA073141

GENE INFORMATION

Gene name

 EN1

Synonyms

Description

 Engrailed homeobox 1 (HGNC Symbol)

Entrez gene summary

 Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.2

Chromosome location (bp)

 118842171 - 118847678

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163064 (version 83.38)

Entrez gene

 2019

UniProt

 Q05925 (UniProt - Inferred from homology)

neXtProt

 NX_Q05925

Antibodypedia

 EN1 antibodies

PROTEIN BROWSER
EN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EN1-001
ENSP00000295206
ENST00000295206
Q05925 [Direct mapping]
Homeobox protein engrailed-1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001501 [skeletal system development]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0009953 [dorsal/ventral pattern formation]
GO:0009954 [proximal/distal pattern formation]
GO:0010468 [regulation of gene expression]
GO:0030182 [neuron differentiation]
GO:0030326 [embryonic limb morphogenesis]
GO:0030901 [midbrain development]
GO:0030902 [hindbrain development]
GO:0030917 [midbrain-hindbrain boundary development]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035264 [multicellular organism growth]
GO:0043473 [pigmentation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048666 [neuron development]
GO:0060173 [limb development]
Show all
 392 aa
40.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.