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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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EN1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

EN1

Gene description

Engrailed homeobox 1

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (skeletal muscle, skin, lymph node, adipose tissue, breast)
GTEx:Group enriched (skin, skeletal muscle, adipose tissue, breast)
FANTOM5:Tissue enhanced (skeletal muscle, adipose tissue)

Protein evidence

Evidence at protein level

Protein expression

Distinct nuclear expression in sweat glands.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA073141
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, skin, lymph node, adipose tissue, breast)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skin, skeletal muscle, adipose tissue, breast)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle, adipose tissue)

GENE INFORMATION

Gene name

EN1

Synonyms

Description

Engrailed homeobox 1 (HGNC Symbol)

Entrez gene summary

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.2

Chromosome location (bp)

118842171 - 118847678

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163064 (version 83.38)

Entrez gene

2019

UniProt

Q05925 (UniProt - Inferred from homology)

neXtProt

NX_Q05925

Antibodypedia

EN1 antibodies

PROTEIN BROWSER

EN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EN1-001
ENSP00000295206
ENST00000295206
Q05925 [Direct mapping]
Homeobox protein engrailed-1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001501 [skeletal system development]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0009953 [dorsal/ventral pattern formation]
GO:0009954 [proximal/distal pattern formation]
GO:0010468 [regulation of gene expression]
GO:0030182 [neuron differentiation]
GO:0030326 [embryonic limb morphogenesis]
GO:0030901 [midbrain development]
GO:0030902 [hindbrain development]
GO:0030917 [midbrain-hindbrain boundary development]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035264 [multicellular organism growth]
GO:0043473 [pigmentation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048666 [neuron development]
GO:0060173 [limb development]
Show all
392 aa
40.1 kDa
No 0

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