Cell atlas - NOSTRIN - The Human Protein Atlas

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NOSTRIN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	NOSTRIN
Gene description	Nitric oxide synthase trafficking
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HEL, K-562, BEWO)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, K-562, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	NOSTRIN (HGNC Symbol)
Synonyms	MGC20702
Description	Nitric oxide synthase trafficking (HGNC Symbol)
Entrez gene summary	Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]
Chromosome	2
Cytoband	q24.3
Chromosome location (bp)	168786539 - 168865514
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163072 (version 83.38)
Entrez gene	115677
UniProt	Q8IVI9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVI9
Antibodypedia	NOSTRIN antibodies

PROTEIN BROWSER

NOSTRIN-001	NOSTRIN-002	NOSTRIN-003	NOSTRIN-004	NOSTRIN-007	NOSTRIN-012	NOSTRIN-013	NOSTRIN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOSTRIN-001 ENSP00000318921 ENST00000317647	Q8IVI9 [Direct mapping] Nostrin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007165 [signal transduction] GO:0030666 [endocytic vesicle membrane] GO:0044281 [small molecule metabolic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] Show all	506 aa 57.7 kDa	No	0
NOSTRIN-002 ENSP00000402140 ENST00000458381	Q8IVI9 [Direct mapping] Nostrin Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007165 [signal transduction] GO:0030666 [endocytic vesicle membrane] GO:0044281 [small molecule metabolic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] Show all	563 aa 64.4 kDa	No	0
NOSTRIN-003 ENSP00000404413 ENST00000445023	Q8IVI9 [Direct mapping] Nostrin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007165 [signal transduction] GO:0030666 [endocytic vesicle membrane] GO:0044281 [small molecule metabolic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] Show all	428 aa 48.9 kDa	No	0
NOSTRIN-004 ENSP00000380392 ENST00000397209	Q8IVI9 [Direct mapping] Nostrin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007165 [signal transduction] GO:0030666 [endocytic vesicle membrane] GO:0044281 [small molecule metabolic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] Show all	478 aa 54.5 kDa	No	0
NOSTRIN-007 ENSP00000390383 ENST00000447264	E9PDM0 [Direct mapping] Nostrin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 19.4 kDa	No	0
NOSTRIN-012 ENSP00000380390 ENST00000397206	Q8IVI9 [Direct mapping] Nostrin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007165 [signal transduction] GO:0030666 [endocytic vesicle membrane] GO:0044281 [small molecule metabolic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] Show all	428 aa 48.9 kDa	No	0
NOSTRIN-013 ENSP00000485819 ENST00000628859	Q8IVI9 [Direct mapping] Nostrin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007165 [signal transduction] GO:0030666 [endocytic vesicle membrane] GO:0044281 [small molecule metabolic process] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] Show all	478 aa 54.5 kDa	No	0
NOSTRIN-201 ENSP00000394051 ENST00000444448	Q8IVI9 [Direct mapping] Nostrin Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007165 [signal transduction] GO:0030666 [endocytic vesicle membrane] GO:0044281 [small molecule metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046209 [nitric oxide metabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] Show all	563 aa 64.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.