Fields »
ABOUT
HELP
BLOG
NOSTRIN

GENERAL INFORMATION

Gene name

 NOSTRIN

Gene description

 Nitric oxide synthase trafficking

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic and membranous expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044384
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NOSTRIN (HGNC Symbol)

Synonyms

 MGC20702

Description

 Nitric oxide synthase trafficking (HGNC Symbol)

Entrez gene summary

 Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

Chromosome

 2

Cytoband

 q24.3

Chromosome location (bp)

 168786539 - 168865514

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163072 (version 83.38)

Entrez gene

 115677

UniProt

 Q8IVI9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IVI9

Antibodypedia

 NOSTRIN antibodies

PROTEIN BROWSER
NOSTRIN-001
NOSTRIN-002
NOSTRIN-003
NOSTRIN-004
NOSTRIN-007
NOSTRIN-012
NOSTRIN-013
NOSTRIN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOSTRIN-001
ENSP00000318921
ENST00000317647
Q8IVI9 [Direct mapping]
Nostrin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0030666 [endocytic vesicle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 506 aa
57.7 kDa 		No 0
NOSTRIN-002
ENSP00000402140
ENST00000458381
Q8IVI9 [Direct mapping]
Nostrin
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0030666 [endocytic vesicle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 563 aa
64.4 kDa 		No 0
NOSTRIN-003
ENSP00000404413
ENST00000445023
Q8IVI9 [Direct mapping]
Nostrin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0030666 [endocytic vesicle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 428 aa
48.9 kDa 		No 0
NOSTRIN-004
ENSP00000380392
ENST00000397209
Q8IVI9 [Direct mapping]
Nostrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0030666 [endocytic vesicle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 478 aa
54.5 kDa 		No 0
NOSTRIN-007
ENSP00000390383
ENST00000447264
E9PDM0 [Direct mapping]
Nostrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 165 aa
19.4 kDa 		No 0
NOSTRIN-012
ENSP00000380390
ENST00000397206
Q8IVI9 [Direct mapping]
Nostrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0030666 [endocytic vesicle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 428 aa
48.9 kDa 		No 0
NOSTRIN-013
ENSP00000485819
ENST00000628859
Q8IVI9 [Direct mapping]
Nostrin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0030666 [endocytic vesicle membrane]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 478 aa
54.5 kDa 		No 0
NOSTRIN-201
ENSP00000394051
ENST00000444448
Q8IVI9 [Direct mapping]
Nostrin
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0030666 [endocytic vesicle membrane]
GO:0044281 [small molecule metabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046209 [nitric oxide metabolic process]
GO:0050999 [regulation of nitric-oxide synthase activity]
Show all
 563 aa
64.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.