Expression of HPGDS in cancer - Summary

CANCER ATLAS

Gene description

Hematopoietic prostaglandin D synthase

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA024035

GENE INFORMATION
Gene name	HPGDS (HGNC Symbol)
Synonyms	GSTS, GSTS1, GSTS1-1, H-PGDS, PGD2, PGDS
Description	Hematopoietic prostaglandin D synthase (HGNC Symbol)
Entrez gene summary	Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q22.3
Chromosome location (bp)	94298535 - 94342876
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163106 (version 83.38)
Entrez gene	27306
UniProt	O60760 (UniProt - Evidence at protein level)
neXtProt	NX_O60760
Antibodypedia	HPGDS antibodies

PROTEIN BROWSER

HPGDS-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HPGDS-001 ENSP00000295256 ENST00000295256	O60760 [Direct mapping] Hematopoietic prostaglandin D synthase Show all	Enzymes ENZYME proteins Transferases Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004364 [glutathione transferase activity] GO:0004667 [prostaglandin-D synthase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006693 [prostaglandin metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0007626 [locomotory behavior] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:1901687 [glutathione derivative biosynthetic process] GO:2000255 [negative regulation of male germ cell proliferation] Show all	199 aa 23.3 kDa	No	0