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HPGDS

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GENERAL INFORMATION

Gene name

 HPGDS

Gene description

 Hematopoietic prostaglandin D synthase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (HEL, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HEL, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HPGDS (HGNC Symbol)

Synonyms

 GSTS, GSTS1, GSTS1-1, H-PGDS, PGD2, PGDS

Description

 Hematopoietic prostaglandin D synthase (HGNC Symbol)

Entrez gene summary

 Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q22.3

Chromosome location (bp)

 94298535 - 94342876

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163106 (version 83.38)

Entrez gene

 27306

UniProt

 O60760 (UniProt - Evidence at protein level)

neXtProt

 NX_O60760

Antibodypedia

 HPGDS antibodies

PROTEIN BROWSER
HPGDS-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HPGDS-001
ENSP00000295256
ENST00000295256
O60760 [Direct mapping]
Hematopoietic prostaglandin D synthase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004364 [glutathione transferase activity]
GO:0004667 [prostaglandin-D synthase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006693 [prostaglandin metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007165 [signal transduction]
GO:0007626 [locomotory behavior]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:1901687 [glutathione derivative biosynthetic process]
GO:2000255 [negative regulation of male germ cell proliferation]
Show all
 199 aa
23.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.