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Most cancers showed weak to moderate cytoplasmic positivity. Liver cancers displayed moderate nuclear staining. Thyroid displayed moderate to strong cytoplasmic staining. Several cases of gliomas, lymphomas, skin and renal cancers were negative.
Most cancer tissues showed weak to moderate, granular cytoplasmic immunoreactivity with additional nuclear staining in several cases. Most thyroid cancers were strongly stained.
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006006 [glucose metabolic process] GO:0006086 [acetyl-CoA biosynthetic process from pyruvate] GO:0006090 [pyruvate metabolic process] GO:0006099 [tricarboxylic acid cycle] GO:0008152 [metabolic process] GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor] GO:0043231 [intracellular membrane-bounded organelle] GO:0045254 [pyruvate dehydrogenase complex]
