Cell atlas - PDHA2 - The Human Protein Atlas

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PDHA2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	PDHA2
Gene description	Pyruvate dehydrogenase (lipoamide) alpha 2
Protein class	Citric acid cycle related proteins Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA047864
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047864	HeLa	Mitochondria
	HPA047864	PC-3	Mitochondria	Intensity
	HPA047864	U-2 OS	Nucleoli
	HPA047864	U-2 OS	Mitochondria	Intensity

GENE INFORMATION
Gene name	PDHA2 (HGNC Symbol)
Synonyms	PDHAL
Description	Pyruvate dehydrogenase (lipoamide) alpha 2 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q22.3
Chromosome location (bp)	95840019 - 95841474
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163114 (version 83.38)
Entrez gene	5161
UniProt	P29803 (UniProt - Evidence at protein level)
neXtProt	NX_P29803
Antibodypedia	PDHA2 antibodies

PROTEIN BROWSER

PDHA2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDHA2-001 ENSP00000295266 ENST00000295266	P29803 [Direct mapping] Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006006 [glucose metabolic process] GO:0006086 [acetyl-CoA biosynthetic process from pyruvate] GO:0006090 [pyruvate metabolic process] GO:0006099 [tricarboxylic acid cycle] GO:0008152 [metabolic process] GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor] GO:0043231 [intracellular membrane-bounded organelle] GO:0045254 [pyruvate dehydrogenase complex] Show all	388 aa 42.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.