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ARPC2

GENERAL INFORMATION

Gene name

 ARPC2

Gene description

 Actin related protein 2/3 complex, subunit 2, 34kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic and membrane expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA008352 , CAB001994
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARPC2 (HGNC Symbol)

Synonyms

 ARC34, p34-Arc

Description

 Actin related protein 2/3 complex, subunit 2, 34kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218217094 - 218254356

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163466 (version 83.38)

Entrez gene

 10109

UniProt

 O15144 (UniProt - Evidence at protein level)

neXtProt

 NX_O15144

Antibodypedia

 ARPC2 antibodies

PROTEIN BROWSER
ARPC2-001
ARPC2-002
ARPC2-015
ARPC2-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARPC2-001
ENSP00000295685
ENST00000295685
O15144 [Direct mapping]
Actin-related protein 2/3 complex subunit 2
Q53R19 [Target identity:100%; Query identity:100%]
Actin related protein 2/3 complex, subunit 2, 34kDa, isoform CRA_a; Putative uncharacterized protein ARPC2; cDNA FLJ76076, highly similar to Homo sapiens actin related protein 2/3 complex, subunit 2, 34kDa (ARPC2), transcript variant 2, mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0015629 [actin cytoskeleton]
GO:0030833 [regulation of actin filament polymerization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031252 [cell leading edge]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0036195 [muscle cell projection membrane]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043005 [neuron projection]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
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 300 aa
34.3 kDa 		No 0
ARPC2-002
ENSP00000327137
ENST00000315717
O15144 [Direct mapping]
Actin-related protein 2/3 complex subunit 2
Q53R19 [Target identity:100%; Query identity:100%]
Actin related protein 2/3 complex, subunit 2, 34kDa, isoform CRA_a; Putative uncharacterized protein ARPC2; cDNA FLJ76076, highly similar to Homo sapiens actin related protein 2/3 complex, subunit 2, 34kDa (ARPC2), transcript variant 2, mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0015629 [actin cytoskeleton]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043005 [neuron projection]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
Show all
 300 aa
34.3 kDa 		No 0
ARPC2-015
ENSP00000411612
ENST00000456575
H7C3F9 [Direct mapping]
Actin-related protein 2/3 complex subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005885 [Arp2/3 protein complex]
GO:0015629 [actin cytoskeleton]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 165 aa
18.7 kDa 		No 0
ARPC2-016
ENSP00000401070
ENST00000420104
C9JTV5 [Direct mapping]
Actin-related protein 2/3 complex subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 90 aa
10 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.