Cell atlas - RNF25 - The Human Protein Atlas

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RNF25

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RNF25
Gene description	Ring finger protein 25
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA036420 , HPA036421
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

Cytosol (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA036420	MCF7	Nucleoplasm
HPA036420	U-2 OS	Cytosol
HPA036420	U-251 MG	Nucleoplasm
HPA036420	U-251 MG	Cytosol
HPA036421	A-431	Cytosol
HPA036421	U-2 OS	Actin filaments
HPA036421	U-2 OS	Cytosol
HPA036421	U-251 MG	Cytosol

GENE INFORMATION
Gene name	RNF25 (HGNC Symbol)
Synonyms	AO7, FLJ13906
Description	Ring finger protein 25 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218663864 - 218672411
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163481 (version 83.38)
Entrez gene	64320
UniProt	Q96BH1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BH1
Antibodypedia	RNF25 antibodies

PROTEIN BROWSER

RNF25-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF25-001 ENSP00000295704 ENST00000295704	Q96BH1 [Direct mapping] E3 ubiquitin-protein ligase RNF25 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0061630 [ubiquitin protein ligase activity] Show all	459 aa 51.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.