Tissue expression of HDAC11 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HDAC11
Gene description	Histone deacetylase 11
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	HDAC11
Synonyms
Description	Histone deacetylase 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
Chromosome	3
Cytoband	p25.1
Chromosome location (bp)	13479724 - 13506424
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163517 (version 83.38)
Entrez gene	79885
UniProt	Q96DB2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96DB2
Antibodypedia	HDAC11 antibodies

PROTEIN BROWSER

HDAC11-001	HDAC11-002	HDAC11-004	HDAC11-005	HDAC11-007	HDAC11-008	HDAC11-009	HDAC11-010	HDAC11-012	HDAC11-013	HDAC11-014	HDAC11-015	HDAC11-017	HDAC11-020	HDAC11-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HDAC11-001 ENSP00000295757 ENST00000295757	Q96DB2 [Direct mapping] Histone deacetylase 11 A0A024R2I1 [Target identity:100%; Query identity:100%] Histone deacetylase 11, isoform CRA_i Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0014003 [oligodendrocyte development] GO:0016568 [chromatin modification] GO:0016575 [histone deacetylation] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0070062 [extracellular exosome] GO:0070932 [histone H3 deacetylation] Show all	347 aa 39.2 kDa	No	0
HDAC11-002 ENSP00000412514 ENST00000433119	Q658J9 [Direct mapping] Histone deacetylase 11; Histone deacetylase 11, isoform CRA_b; Putative uncharacterized protein DKFZp434L0312 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	236 aa 25.9 kDa	No	0
HDAC11-004 ENSP00000384706 ENST00000402259	B5MCS3 [Direct mapping] Histone deacetylase 11 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	181 aa 20.4 kDa	No	0
HDAC11-005 ENSP00000384123 ENST00000402271	B5MCQ6 [Direct mapping] Histone deacetylase 11 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	268 aa 30.7 kDa	No	0
HDAC11-007 ENSP00000385475 ENST00000404040	B5MCU6 [Direct mapping] Histone deacetylase 11 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	247 aa 28.3 kDa	No	0
HDAC11-008 ENSP00000385528 ENST00000404548	B5MC52 [Direct mapping] Histone deacetylase 11 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	146 aa 16.9 kDa	No	0
HDAC11-009 ENSP00000384019 ENST00000405025	B5MD06 [Direct mapping] Histone deacetylase 11; Histone deacetylase 11, isoform CRA_h Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	118 aa 13.4 kDa	No	0
HDAC11-010 ENSP00000385252 ENST00000405478	B5MCV5 [Direct mapping] Histone deacetylase 11 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Show all		204 aa 23.2 kDa	No	0
HDAC11-012 ENSP00000411792 ENST00000418189	C9J528 [Direct mapping] Histone deacetylase 11 Show all	Predicted intracellular proteins Show all		107 aa 12.4 kDa	No	0
HDAC11-013 ENSP00000398651 ENST00000434848	C9JBI4 [Direct mapping] Histone deacetylase 11 Show all	Predicted intracellular proteins Show all		168 aa 18.7 kDa	No	0
HDAC11-014 ENSP00000402298 ENST00000416248	C9JMH0 [Direct mapping] Histone deacetylase 11 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Show all		92 aa 10.6 kDa	No	0
HDAC11-015 ENSP00000396122 ENST00000455904	C9JEC8 [Direct mapping] Histone deacetylase 11 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Show all		166 aa 18.6 kDa	No	0
HDAC11-017 ENSP00000395188 ENST00000437379	E7ETT9 [Direct mapping] Histone deacetylase 11 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	319 aa 35.7 kDa	No	0
HDAC11-020 ENSP00000429794 ENST00000522202	Q96DB2 [Direct mapping] Histone deacetylase 11 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0004407 [histone deacetylase activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0016568 [chromatin modification] GO:0016575 [histone deacetylation] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0070062 [extracellular exosome] GO:0070932 [histone H3 deacetylation] Show all	296 aa 33.1 kDa	No	0
HDAC11-201 ENSP00000401487 ENST00000446613	Q658J9 [Direct mapping] Histone deacetylase 11; Histone deacetylase 11, isoform CRA_b; Putative uncharacterized protein DKFZp434L0312 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	236 aa 25.9 kDa	No	0