Expression of SUCLG1 in cancer - Summary

CANCER ATLAS

Gene description

Succinate-CoA ligase, alpha subunit

Protein class

Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036683	HPA036684

GENE INFORMATION
Gene name	SUCLG1
Synonyms
Description	Succinate-CoA ligase, alpha subunit (HGNC Symbol)
Entrez gene summary	This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]
Chromosome	2
Cytoband	p11.2
Chromosome location (bp)	84423523 - 84460045
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163541 (version 83.38)
Entrez gene	8802
UniProt	P53597 (UniProt - Evidence at protein level)
neXtProt	NX_P53597
Antibodypedia	SUCLG1 antibodies

PROTEIN BROWSER

SUCLG1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SUCLG1-001 ENSP00000377446 ENST00000393868	P53597 [Direct mapping] Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Citric acid cycle related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004775 [succinate-CoA ligase (ADP-forming) activity] GO:0004776 [succinate-CoA ligase (GDP-forming) activity] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0006099 [tricarboxylic acid cycle] GO:0006104 [succinyl-CoA metabolic process] GO:0006105 [succinate metabolic process] GO:0008152 [metabolic process] GO:0009142 [nucleoside triphosphate biosynthetic process] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048037 [cofactor binding] GO:0070062 [extracellular exosome] Show all	346 aa 36.2 kDa	Yes	0