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PTPN13

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GENERAL INFORMATION

Gene name

 PTPN13

Gene description

 Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cytosol.

RNA cell category

 Cell line enhanced (AF22)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA065290
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cytosol.

Main location

 Plasma membrane (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA065290 BJ Cytosol
HPA065290 RT4 Plasma membrane
HPA065290 U-2 OS Cytosol

GENE INFORMATION

Gene name

 PTPN13 (HGNC Symbol)

Synonyms

 PTP-BAS, PTP-BL, PTP1E, PTPL1

Description

 Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

Chromosome

 4

Cytoband

 q21.3

Chromosome location (bp)

 86594315 - 86815171

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163629 (version 83.38)

Entrez gene

 5783

UniProt

 Q12923 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12923

Antibodypedia

 PTPN13 antibodies

PROTEIN BROWSER
PTPN13-001
PTPN13-002
PTPN13-003
PTPN13-005
PTPN13-006
PTPN13-008
PTPN13-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTPN13-001
ENSP00000408368
ENST00000427191
Q12923 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 13
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030027 [lamellipodium]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0070062 [extracellular exosome]
Show all
 2466 aa
274.9 kDa 		No 0
PTPN13-002
ENSP00000322675
ENST00000316707
Q12923 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 13
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030027 [lamellipodium]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0070062 [extracellular exosome]
Show all
 2294 aa
255.9 kDa 		No 0
PTPN13-003
ENSP00000407249
ENST00000411767
Q12923 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 13
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030027 [lamellipodium]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0070062 [extracellular exosome]
Show all
 2485 aa
276.9 kDa 		No 0
PTPN13-005
ENSP00000426626
ENST00000511467
Q12923 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 13
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030027 [lamellipodium]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0070062 [extracellular exosome]
Show all
 2490 aa
277.5 kDa 		No 0
PTPN13-006
ENSP00000423531
ENST00000502971
D6R9M4 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 13
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0070830 [bicellular tight junction assembly]
Show all
 227 aa
25 kDa 		No 0
PTPN13-008
ENSP00000422835
ENST00000507902
D6R9X4 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 13
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070830 [bicellular tight junction assembly]
Show all
 139 aa
15.3 kDa 		No 0
PTPN13-201
ENSP00000394794
ENST00000436978
Q12923 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 13
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030027 [lamellipodium]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0043005 [neuron projection]
GO:0044297 [cell body]
GO:0070062 [extracellular exosome]
Show all
 2490 aa
277.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.