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Malignancies were in general weakly stained in the cytoplasm or negative. Malignant melanomas and thyroid cancers as well as cases of urothelial and renal cancers showed moderate positivity.
Hepatocellular carcinoma and several cases of urothelial, ovarian, pancreatic and prostate cancer showed moderate cytoplasmic positivity. Remaining malignancies were negative or weakly stained.
GENE INFORMATION
Gene name
ADAMTS9 (HGNC Symbol)
Synonyms
KIAA1312
Description
ADAM metallopeptidase with thrombospondin type 1 motif, 9 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. [provided by RefSeq, Jul 2008]
