Cell atlas - ADAMTS9 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ADAMTS9

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Vesicles

Human cell
	Endoplasmic Reticulum
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ADAMTS9
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 9
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (SH-SY5Y, WM-115)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Endoplasmic reticulum (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA028601
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, WM-115) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the endoplasmic reticulum.

Main location

Vesicles (approved)

Additional location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028601	AF22	Endoplasmic reticulum
	HPA028601	AF22	Vesicles	Intensity
	HPA028601	U-2 OS	Endoplasmic reticulum
	HPA028601	U-2 OS	Vesicles	Intensity

GENE INFORMATION
Gene name	ADAMTS9 (HGNC Symbol)
Synonyms	KIAA1312
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 9 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p14.1
Chromosome location (bp)	64515654 - 64688000
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163638 (version 83.38)
Entrez gene	56999
UniProt	Q9P2N4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2N4
Antibodypedia	ADAMTS9 antibodies

PROTEIN BROWSER

ADAMTS9-001	ADAMTS9-002	ADAMTS9-003	ADAMTS9-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS9-001 ENSP00000418735 ENST00000498707	Q9P2N4 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 9 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0005783 [endoplasmic reticulum] GO:0006508 [proteolysis] GO:0006516 [glycoprotein catabolic process] GO:0007275 [multicellular organismal development] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0031012 [extracellular matrix] Show all	1935 aa 216.5 kDa	Yes	0
ADAMTS9-002 ENSP00000419217 ENST00000459780	C9JWI2 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 9 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	488 aa 55.1 kDa	Yes	0
ADAMTS9-003 ENSP00000295903 ENST00000295903	Q9P2N4 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 9 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0005783 [endoplasmic reticulum] GO:0006508 [proteolysis] GO:0006516 [glycoprotein catabolic process] GO:0007275 [multicellular organismal development] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0031012 [extracellular matrix] Show all	1907 aa 213.4 kDa	Yes	0
ADAMTS9-006 ENSP00000417521 ENST00000481060	H0Y859 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 9 Show all	Predicted intracellular proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	991 aa 110.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.