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APBB2

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GENERAL INFORMATION

Gene name

 APBB2

Gene description

 Amyloid beta (A4) precursor protein-binding, family B, member 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 18
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Cell line enhanced (TIME)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA023542
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA023542 A-431 Mitochondria
HPA023542 U-2 OS Mitochondria
HPA023542 U-251 MG Mitochondria Intensity

GENE INFORMATION

Gene name

 APBB2 (HGNC Symbol)

Synonyms

 FE65L, FE65L1, MGC35575

Description

 Amyloid beta (A4) precursor protein-binding, family B, member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 4

Cytoband

Chromosome location (bp)

 40810027 - 41216714

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163697 (version 83.38)

Entrez gene

 323

UniProt

 Q92870 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92870

Antibodypedia

 APBB2 antibodies

PROTEIN BROWSER
«
APBB2-001
APBB2-002
APBB2-003
APBB2-006
APBB2-007
APBB2-010
APBB2-012
APBB2-016
APBB2-018
APBB2-019
APBB2-020
APBB2-023
APBB2-025
APBB2-026
APBB2-027
APBB2-028
APBB2-029
APBB2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APBB2-001
ENSP00000426018
ENST00000513140
Q92870 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008134 [transcription factor binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0035556 [intracellular signal transduction]
GO:0045202 [synapse]
Show all
 736 aa
80.9 kDa 		No 0
APBB2-002
ENSP00000295974
ENST00000295974
Q92870 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008134 [transcription factor binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0035556 [intracellular signal transduction]
GO:0045202 [synapse]
Show all
 758 aa
83.4 kDa 		No 0
APBB2-003
ENSP00000427211
ENST00000508593
Q92870 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0007411 [axon guidance]
GO:0008134 [transcription factor binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045202 [synapse]
Show all
 759 aa
83.4 kDa 		No 0
APBB2-006
ENSP00000427307
ENST00000513611
H0YAJ5 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 728 aa
80 kDa 		No 0
APBB2-007
ENSP00000425802
ENST00000502841
Q92870 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008134 [transcription factor binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0035556 [intracellular signal transduction]
GO:0045202 [synapse]
Show all
 210 aa
23.5 kDa 		No 0
APBB2-010
ENSP00000422723
ENST00000508676
D6RAE0 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 27 aa
2.7 kDa 		No 0
APBB2-012
ENSP00000421539
ENST00000506352
G5E9Y1 [Direct mapping]
Amyloid beta (A4) protein-binding, family B, member 2 (Fe65-like), isoform CRA_c; Amyloid beta A4 precursor protein-binding family B member 2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 737 aa
81 kDa 		No 0
APBB2-016
ENSP00000421205
ENST00000503503
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 10 aa
1 kDa 		No 0
APBB2-018
ENSP00000424579
ENST00000508707
D6RB00 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 68 aa
7.3 kDa 		No 0
APBB2-019
ENSP00000425202
ENST00000503264
D6RDY3 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 26 aa
2.7 kDa 		No 0
APBB2-020
ENSP00000424414
ENST00000509446
D6RB55 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 140 aa
15.1 kDa 		No 0
APBB2-023
ENSP00000425121
ENST00000513493
H0Y9U9 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 142 aa
15.9 kDa 		No 0
APBB2-025
ENSP00000423765
ENST00000504305
Q92870 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008134 [transcription factor binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0035556 [intracellular signal transduction]
GO:0045202 [synapse]
Show all
 210 aa
23.5 kDa 		No 0
APBB2-026
ENSP00000427107
ENST00000510670
D6RD19 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 102 aa
11.3 kDa 		No 0
APBB2-027
ENSP00000421301
ENST00000513516
D6RGD4 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 87 aa
9.6 kDa 		No 0
APBB2-028
ENSP00000421751
ENST00000514920
D6RAJ4 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 95 aa
10.5 kDa 		No 0
APBB2-029
ENSP00000426429
ENST00000512510
H0YA92 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
Show all
 180 aa
20.2 kDa 		No 0
APBB2-201
ENSP00000439357
ENST00000543538
Q92870 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008134 [transcription factor binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0035556 [intracellular signal transduction]
GO:0045202 [synapse]
Show all
 210 aa
23.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.