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TOPBP1

GENERAL INFORMATION

Gene name

 TOPBP1

Gene description

 Topoisomerase (DNA) II binding protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB022451
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TOPBP1 (HGNC Symbol)

Synonyms

 KIAA0259, TOP2BP1

Description

 Topoisomerase (DNA) II binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q22.1

Chromosome location (bp)

 133598175 - 133661893

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163781 (version 83.38)

Entrez gene

 11073

UniProt

 Q92547 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92547

Antibodypedia

 TOPBP1 antibodies

PROTEIN BROWSER
TOPBP1-001
TOPBP1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOPBP1-001
ENSP00000260810
ENST00000260810
Q92547 [Direct mapping]
DNA topoisomerase 2-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000724 [double-strand break repair via homologous recombination]
GO:0000794 [condensed nuclear chromosome]
GO:0000922 [spindle pole]
GO:0001673 [male germ cell nucleus]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006259 [DNA metabolic process]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008022 [protein C-terminus binding]
GO:0010212 [response to ionizing radiation]
GO:0015629 [actin cytoskeleton]
GO:0016605 [PML body]
GO:0042802 [identical protein binding]
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 1522 aa
170.7 kDa 		No 0
TOPBP1-003
ENSP00000421179
ENST00000508524
H0Y8I7 [Direct mapping]
DNA topoisomerase 2-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 206 aa
23.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.