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Cancer tissues displayed moderate to strong cytoplasmic and/or nuclear staining. Membranous positivity was observed in colorectal cancers. Most of the cases of skin, liver, cervical and prostate cancers were weakly stained or negative.
ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]