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ZC3H12A

GENERAL INFORMATION

Gene name

 ZC3H12A

Gene description

 Zinc finger CCCH-type containing 12A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (bone marrow)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at varying intensities in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA032052 , HPA032053
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ZC3H12A (HGNC Symbol)

Synonyms

 FLJ23231, MCPIP1

Description

 Zinc finger CCCH-type containing 12A (HGNC Symbol)

Entrez gene summary

 ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 37474552 - 37484379

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163874 (version 83.38)

Entrez gene

 80149

UniProt

 Q5D1E8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5D1E8

Antibodypedia

 ZC3H12A antibodies

PROTEIN BROWSER
ZC3H12A-001
ZC3H12A-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZC3H12A-001
ENSP00000362179
ENST00000373087
Q5D1E8 [Direct mapping]
Ribonuclease ZC3H12A
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0010508 [positive regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010884 [positive regulation of lipid storage]
GO:0030154 [cell differentiation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0043031 [negative regulation of macrophage activation]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0046872 [metal ion binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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 599 aa
65.7 kDa 		No 0
ZC3H12A-005
ENSP00000473447
ENST00000471012
R4GN17 [Direct mapping]
Ribonuclease ZC3H12A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 131 aa
14.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.