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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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SENP2
  • TISSUE

  • premium

    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

SUMO1/sentrin/SMT3 specific peptidase 2

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA029247
HPA029248

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells showed weak to moderate cytoplasmic positivity with additional membranous staining in several cases. Strong immunoreactivity was observed in few cases of testicular, ovarian and gastric cancers while most endometrial and renal cancers were negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most of the cancer cells displayed moderate to strong cytoplasmic positivity. Carcinoids were weakly stained or negative.

GENE INFORMATION

Gene name

SENP2 (HGNC Symbol)

Synonyms

AXAM2, DKFZp762A2316, KIAA1331, SMT3IP2

Description

SUMO1/sentrin/SMT3 specific peptidase 2 (HGNC Symbol)

Entrez gene summary

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

Chromosome

3

Cytoband

q27.2

Chromosome location (bp)

185582496 - 185633551

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163904 (version 83.38)

Entrez gene

59343

UniProt

Q9HC62 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HC62

Antibodypedia

SENP2 antibodies

PROTEIN BROWSER

SENP2-001
SENP2-004
SENP2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SENP2-001
ENSP00000296257
ENST00000296257
Q9HC62 [Direct mapping]
Sentrin-specific protease 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004175 [endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0007507 [heart development]
GO:0008234 [cysteine-type peptidase activity]
GO:0009950 [dorsal/ventral axis specification]
GO:0015031 [protein transport]
GO:0016055 [Wnt signaling pathway]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0016926 [protein desumoylation]
GO:0016929 [SUMO-specific protease activity]
GO:0019904 [protein domain specific binding]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031648 [protein destabilization]
GO:0031965 [nuclear membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032875 [regulation of DNA endoreduplication]
GO:0035562 [negative regulation of chromatin binding]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045444 [fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051028 [mRNA transport]
GO:0051246 [regulation of protein metabolic process]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060711 [labyrinthine layer development]
GO:0060712 [spongiotrophoblast layer development]
GO:1901797 [negative regulation of signal transduction by p53 class mediator]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
589 aa
67.9 kDa
No 0
SENP2-004
ENSP00000399156
ENST00000430355
C9IYB7 [Direct mapping]
Sentrin-specific protease 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
273 aa
30.1 kDa
No 0
SENP2-012
ENSP00000399201
ENST00000444509
H7C1A0 [Direct mapping]
Sentrin-specific protease 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
Show all
203 aa
23.8 kDa
No 0

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