Expression of RHO in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Rhodopsin

Protein class

Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA013440	CAB022486

GENE INFORMATION
Gene name	RHO (HGNC Symbol)
Synonyms	CSNBAD1, OPN2, RP4
Description	Rhodopsin (HGNC Symbol)
Entrez gene summary	Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	129528640 - 129535169
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163914 (version 83.38)
Entrez gene	6010
UniProt	P08100 (UniProt - Evidence at protein level)
neXtProt	NX_P08100
Antibodypedia	RHO antibodies

PROTEIN BROWSER

RHO-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RHO-001 ENSP00000296271 ENST00000296271	P08100 [Direct mapping] Rhodopsin Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Opsins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001523 [retinoid metabolic process] GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0006996 [organelle organization] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0007603 [phototransduction, visible light] GO:0009416 [response to light stimulus] GO:0009583 [detection of light stimulus] GO:0009585 [red, far-red light phototransduction] GO:0009881 [photoreceptor activity] GO:0016021 [integral component of membrane] GO:0016038 [absorption of visible light] GO:0016056 [rhodopsin mediated signaling pathway] GO:0016918 [retinal binding] GO:0018298 [protein-chromophore linkage] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030660 [Golgi-associated vesicle membrane] GO:0030867 [rough endoplasmic reticulum membrane] GO:0042622 [photoreceptor outer segment membrane] GO:0045494 [photoreceptor cell maintenance] GO:0046872 [metal ion binding] GO:0050953 [sensory perception of light stimulus] GO:0060041 [retina development in camera-type eye] GO:0060170 [ciliary membrane] GO:0060342 [photoreceptor inner segment membrane] GO:0071482 [cellular response to light stimulus] GO:0097381 [photoreceptor disc membrane] Show all	348 aa 38.9 kDa	No	7