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UVSSA

CANCER ATLAS

Gene description

 UV-stimulated scaffold protein A

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050824

GENE INFORMATION

Gene name

 UVSSA (HGNC Symbol)

Synonyms

 KIAA1530

Description

 UV-stimulated scaffold protein A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex to help repair UV-induced DNA damage. Defects in this gene can cause UV-sensitive syndrome 3. [provided by RefSeq, May 2012]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 1347266 - 1388049

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163945 (version 83.38)

Entrez gene

 57654

UniProt

 Q2YD98 (UniProt - Evidence at protein level)

neXtProt

 NX_Q2YD98

Antibodypedia

 UVSSA antibodies

PROTEIN BROWSER
UVSSA-001
UVSSA-002
UVSSA-003
UVSSA-004
UVSSA-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UVSSA-001
ENSP00000374501
ENST00000389851
Q2YD98 [Direct mapping]
UV-stimulated scaffold protein A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0009411 [response to UV]
GO:0016567 [protein ubiquitination]
Show all
 709 aa
80.6 kDa 		No 0
UVSSA-002
ENSP00000425130
ENST00000511216
Q2YD98 [Direct mapping]
UV-stimulated scaffold protein A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0009411 [response to UV]
GO:0016567 [protein ubiquitination]
Show all
 709 aa
80.6 kDa 		No 0
UVSSA-003
ENSP00000421741
ENST00000507531
Q2YD98 [Direct mapping]
UV-stimulated scaffold protein A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0009411 [response to UV]
GO:0016567 [protein ubiquitination]
Show all
 709 aa
80.6 kDa 		No 0
UVSSA-004
ENSP00000423340
ENST00000511563
Q2YD98 [Direct mapping]
UV-stimulated scaffold protein A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0009411 [response to UV]
GO:0016567 [protein ubiquitination]
Show all
 260 aa
29.8 kDa 		No 0
UVSSA-005
ENSP00000427701
ENST00000512728
Q2YD98 [Direct mapping]
UV-stimulated scaffold protein A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0009411 [response to UV]
GO:0016567 [protein ubiquitination]
Show all
 260 aa
29.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.