Cell atlas - UVSSA - The Human Protein Atlas

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UVSSA

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	UVSSA
Gene description	UV-stimulated scaffold protein A
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA053496
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053496	PC-3	Nucleoplasm
	HPA053496	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	UVSSA (HGNC Symbol)
Synonyms	KIAA1530
Description	UV-stimulated scaffold protein A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex to help repair UV-induced DNA damage. Defects in this gene can cause UV-sensitive syndrome 3. [provided by RefSeq, May 2012]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	1347266 - 1388049
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163945 (version 83.38)
Entrez gene	57654
UniProt	Q2YD98 (UniProt - Evidence at protein level)
neXtProt	NX_Q2YD98
Antibodypedia	UVSSA antibodies

PROTEIN BROWSER

UVSSA-001	UVSSA-002	UVSSA-003	UVSSA-004	UVSSA-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UVSSA-001 ENSP00000374501 ENST00000389851	Q2YD98 [Direct mapping] UV-stimulated scaffold protein A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000993 [RNA polymerase II core binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0009411 [response to UV] GO:0016567 [protein ubiquitination] Show all	709 aa 80.6 kDa	No	0
UVSSA-002 ENSP00000425130 ENST00000511216	Q2YD98 [Direct mapping] UV-stimulated scaffold protein A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000993 [RNA polymerase II core binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0009411 [response to UV] GO:0016567 [protein ubiquitination] Show all	709 aa 80.6 kDa	No	0
UVSSA-003 ENSP00000421741 ENST00000507531	Q2YD98 [Direct mapping] UV-stimulated scaffold protein A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000993 [RNA polymerase II core binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0009411 [response to UV] GO:0016567 [protein ubiquitination] Show all	709 aa 80.6 kDa	No	0
UVSSA-004 ENSP00000423340 ENST00000511563	Q2YD98 [Direct mapping] UV-stimulated scaffold protein A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000993 [RNA polymerase II core binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0009411 [response to UV] GO:0016567 [protein ubiquitination] Show all	260 aa 29.8 kDa	No	0
UVSSA-005 ENSP00000427701 ENST00000512728	Q2YD98 [Direct mapping] UV-stimulated scaffold protein A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000993 [RNA polymerase II core binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0009411 [response to UV] GO:0016567 [protein ubiquitination] Show all	260 aa 29.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.