Expression of LRPAP1 in cancer - Summary

CANCER ATLAS

Gene description

Low density lipoprotein receptor-related protein associated protein 1

Protein class

Disease related genes, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008001	CAB025518

GENE INFORMATION
Gene name	LRPAP1 (HGNC Symbol)
Synonyms	A2MRAP, HBP44
Description	Low density lipoprotein receptor-related protein associated protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	3506376 - 3532559
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163956 (version 83.38)
Entrez gene	4043
UniProt	P30533 (UniProt - Evidence at protein level)
neXtProt	NX_P30533
Antibodypedia	LRPAP1 antibodies

PROTEIN BROWSER

LRPAP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRPAP1-001 ENSP00000421922 ENST00000500728	P30533 [Direct mapping] Alpha-2-macroglobulin receptor-associated protein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004873 [asialoglycoprotein receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0006898 [receptor-mediated endocytosis] GO:0008201 [heparin binding] GO:0009986 [cell surface] GO:0010916 [negative regulation of very-low-density lipoprotein particle clearance] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] GO:0031982 [vesicle] GO:0032091 [negative regulation of protein binding] GO:0035473 [lipase binding] GO:0048019 [receptor antagonist activity] GO:0048237 [rough endoplasmic reticulum lumen] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0051082 [unfolded protein binding] GO:0070326 [very-low-density lipoprotein particle receptor binding] GO:1900116 [extracellular negative regulation of signal transduction] GO:1900222 [negative regulation of beta-amyloid clearance] Show all	357 aa 41.5 kDa	Yes	0