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LRPAP1

GENERAL INFORMATION

Gene name

 LRPAP1

Gene description

 Low density lipoprotein receptor-related protein associated protein 1

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA008001 , CAB025518
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LRPAP1 (HGNC Symbol)

Synonyms

 A2MRAP, HBP44

Description

 Low density lipoprotein receptor-related protein associated protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 3506376 - 3532559

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163956 (version 83.38)

Entrez gene

 4043

UniProt

 P30533 (UniProt - Evidence at protein level)

neXtProt

 NX_P30533

Antibodypedia

 LRPAP1 antibodies

PROTEIN BROWSER
LRPAP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LRPAP1-001
ENSP00000421922
ENST00000500728
P30533 [Direct mapping]
Alpha-2-macroglobulin receptor-associated protein
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004873 [asialoglycoprotein receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006898 [receptor-mediated endocytosis]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0010916 [negative regulation of very-low-density lipoprotein particle clearance]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0031982 [vesicle]
GO:0032091 [negative regulation of protein binding]
GO:0035473 [lipase binding]
GO:0048019 [receptor antagonist activity]
GO:0048237 [rough endoplasmic reticulum lumen]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0051082 [unfolded protein binding]
GO:0070326 [very-low-density lipoprotein particle receptor binding]
GO:1900116 [extracellular negative regulation of signal transduction]
GO:1900222 [negative regulation of beta-amyloid clearance]
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 357 aa
41.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.