Expression of PGRMC2 in cancer - Summary

CANCER ATLAS

Gene description

Progesterone receptor membrane component 2

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041172	HPA058652

GENE INFORMATION
Gene name	PGRMC2 (HGNC Symbol)
Synonyms	DG6, PMBP
Description	Progesterone receptor membrane component 2 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q28.2
Chromosome location (bp)	128269237 - 128288829
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164040 (version 83.38)
Entrez gene	10424
UniProt	O15173 (UniProt - Evidence at protein level)
neXtProt	NX_O15173
Antibodypedia	PGRMC2 antibodies

PROTEIN BROWSER

PGRMC2-001	PGRMC2-002	PGRMC2-003	PGRMC2-004	PGRMC2-005	PGRMC2-007	PGRMC2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGRMC2-001 ENSP00000429301 ENST00000520121	O15173 [Direct mapping] Membrane-associated progesterone receptor component 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003707 [steroid hormone receptor activity] GO:0005496 [steroid binding] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0043401 [steroid hormone mediated signaling pathway] Show all	247 aa 26.2 kDa	No	1
PGRMC2-002 ENSP00000475242 ENST00000394276	D3DNX8 [Direct mapping] Membrane-associated progesterone receptor component 2; Progesterone receptor membrane component 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0012505 [endomembrane system] GO:0020037 [heme binding] Show all	44 aa 5.4 kDa	No	0
PGRMC2-003 ENSP00000475350 ENST00000512483	D3DNX8 [Direct mapping] Membrane-associated progesterone receptor component 2; Progesterone receptor membrane component 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0012505 [endomembrane system] GO:0020037 [heme binding] Show all	44 aa 5.4 kDa	No	0
PGRMC2-004 ENSP00000475268 ENST00000503872	D3DNX8 [Direct mapping] Membrane-associated progesterone receptor component 2; Progesterone receptor membrane component 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0012505 [endomembrane system] GO:0020037 [heme binding] Show all	44 aa 5.4 kDa	No	0
PGRMC2-005 ENSP00000476010 ENST00000503588	U3KQM0 [Direct mapping] Membrane-associated progesterone receptor component 2; Progesterone receptor membrane component 2, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0012505 [endomembrane system] GO:0020037 [heme binding] Show all	91 aa 10.5 kDa	No	0
PGRMC2-007 ENSP00000296425 ENST00000296425	O15173 [Direct mapping] Membrane-associated progesterone receptor component 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003707 [steroid hormone receptor activity] GO:0005496 [steroid binding] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0043401 [steroid hormone mediated signaling pathway] Show all	223 aa 23.8 kDa	No	1
PGRMC2-201 ENSP00000481886 ENST00000613358	O15173 [Direct mapping] Membrane-associated progesterone receptor component 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003707 [steroid hormone receptor activity] GO:0005496 [steroid binding] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0043401 [steroid hormone mediated signaling pathway] Show all	247 aa 26.2 kDa	No	1