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PGRMC2

GENERAL INFORMATION

Gene name

 PGRMC2

Gene description

 Progesterone receptor membrane component 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several different tissue types, most abundant in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA041172 , HPA058652
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PGRMC2 (HGNC Symbol)

Synonyms

 DG6, PMBP

Description

 Progesterone receptor membrane component 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q28.2

Chromosome location (bp)

 128269237 - 128288829

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164040 (version 83.38)

Entrez gene

 10424

UniProt

 O15173 (UniProt - Evidence at protein level)

neXtProt

 NX_O15173

Antibodypedia

 PGRMC2 antibodies

PROTEIN BROWSER
PGRMC2-001
PGRMC2-002
PGRMC2-003
PGRMC2-004
PGRMC2-005
PGRMC2-007
PGRMC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGRMC2-001
ENSP00000429301
ENST00000520121
O15173 [Direct mapping]
Membrane-associated progesterone receptor component 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0020037 [heme binding]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 247 aa
26.2 kDa 		No 1
PGRMC2-002
ENSP00000475242
ENST00000394276
D3DNX8 [Direct mapping]
Membrane-associated progesterone receptor component 2; Progesterone receptor membrane component 2, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0012505 [endomembrane system]
GO:0020037 [heme binding]
Show all
 44 aa
5.4 kDa 		No 0
PGRMC2-003
ENSP00000475350
ENST00000512483
D3DNX8 [Direct mapping]
Membrane-associated progesterone receptor component 2; Progesterone receptor membrane component 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0012505 [endomembrane system]
GO:0020037 [heme binding]
Show all
 44 aa
5.4 kDa 		No 0
PGRMC2-004
ENSP00000475268
ENST00000503872
D3DNX8 [Direct mapping]
Membrane-associated progesterone receptor component 2; Progesterone receptor membrane component 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0012505 [endomembrane system]
GO:0020037 [heme binding]
Show all
 44 aa
5.4 kDa 		No 0
PGRMC2-005
ENSP00000476010
ENST00000503588
U3KQM0 [Direct mapping]
Membrane-associated progesterone receptor component 2; Progesterone receptor membrane component 2, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0012505 [endomembrane system]
GO:0020037 [heme binding]
Show all
 91 aa
10.5 kDa 		No 0
PGRMC2-007
ENSP00000296425
ENST00000296425
O15173 [Direct mapping]
Membrane-associated progesterone receptor component 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0020037 [heme binding]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 223 aa
23.8 kDa 		No 1
PGRMC2-201
ENSP00000481886
ENST00000613358
O15173 [Direct mapping]
Membrane-associated progesterone receptor component 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0020037 [heme binding]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 247 aa
26.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.