Cell atlas - ATRIP - The Human Protein Atlas

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ATRIP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ATRIP
Gene description	ATR interacting protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047590
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047590	HeLa	Nucleus
	HPA047590	RH-30	Nucleus
	HPA047590	U-2 OS	Nucleus

GENE INFORMATION
Gene name	ATRIP (HGNC Symbol)
Synonyms	FLJ12343, MGC20625, MGC21482, MGC26740
Description	ATR interacting protein (HGNC Symbol)
Entrez gene summary	This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48446710 - 48465716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164053 (version 83.38)
Entrez gene	84126
UniProt	Q8WXE1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXE1
Antibodypedia	ATRIP antibodies

PROTEIN BROWSER

ATRIP-001	ATRIP-002	ATRIP-005	ATRIP-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATRIP-001 ENSP00000323099 ENST00000320211	Q8WXE1 [Direct mapping] ATR-interacting protein A0A024R2U4 [Target identity:100%; Query identity:100%] Three prime repair exonuclease 1, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000077 [DNA damage checkpoint] GO:0000724 [double-strand break repair via homologous recombination] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0036297 [interstrand cross-link repair] GO:0070530 [K63-linked polyubiquitin binding] Show all	791 aa 85.8 kDa	No	0
ATRIP-002 ENSP00000302338 ENST00000346691	Q8WXE1 [Direct mapping] ATR-interacting protein A0A024R307 [Target identity:100%; Query identity:100%] Three prime repair exonuclease 1, isoform CRA_d Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000077 [DNA damage checkpoint] GO:0000724 [double-strand break repair via homologous recombination] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0036297 [interstrand cross-link repair] GO:0070530 [K63-linked polyubiquitin binding] Show all	764 aa 83 kDa	No	0
ATRIP-005 ENSP00000400930 ENST00000412052	Q8WXE1 [Direct mapping] ATR-interacting protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000077 [DNA damage checkpoint] GO:0000724 [double-strand break repair via homologous recombination] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0036297 [interstrand cross-link repair] GO:0070530 [K63-linked polyubiquitin binding] Show all	698 aa 76.3 kDa	No	0
ATRIP-007 ENSP00000489608 ENST00000635099	C9IZM8 [Target identity:100%; Query identity:100%] ATR-interacting protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	196 aa 22.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.