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F2RL2

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GENERAL INFORMATION

Gene name

 F2RL2

Gene description

 Coagulation factor II (thrombin) receptor-like 2

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (WM-115, HEL, U-138 MG, BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, HEL, U-138 MG, BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 F2RL2 (HGNC Symbol)

Synonyms

 PAR3

Description

 Coagulation factor II (thrombin) receptor-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

Chromosome

 5

Cytoband

 q13.3

Chromosome location (bp)

 76615482 - 76623434

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164220 (version 83.38)

Entrez gene

 2151

UniProt

 O00254 (UniProt - Evidence at protein level)

neXtProt

 NX_O00254

Antibodypedia

 F2RL2 antibodies

PROTEIN BROWSER
F2RL2-001
F2RL2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
F2RL2-001
ENSP00000296641
ENST00000296641
O00254 [Direct mapping]
Proteinase-activated receptor 3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009611 [response to wounding]
GO:0015057 [thrombin receptor activity]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0030168 [platelet activation]
GO:0070493 [thrombin receptor signaling pathway]
Show all
 374 aa
42.5 kDa 		Yes 7
F2RL2-002
ENSP00000426703
ENST00000504899
O00254 [Direct mapping]
Proteinase-activated receptor 3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009611 [response to wounding]
GO:0015057 [thrombin receptor activity]
GO:0016021 [integral component of membrane]
GO:0030168 [platelet activation]
GO:0070493 [thrombin receptor signaling pathway]
Show all
 352 aa
40.2 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.