Tissue expression of F2RL2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	F2RL2
Gene description	Coagulation factor II (thrombin) receptor-like 2
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (gallbladder)
GTEx:	Tissue enhanced (salivary gland)
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (gallbladder)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	F2RL2 (HGNC Symbol)
Synonyms	PAR3
Description	Coagulation factor II (thrombin) receptor-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
Chromosome	5
Cytoband	q13.3
Chromosome location (bp)	76615482 - 76623434
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164220 (version 83.38)
Entrez gene	2151
UniProt	O00254 (UniProt - Evidence at protein level)
neXtProt	NX_O00254
Antibodypedia	F2RL2 antibodies

PROTEIN BROWSER

F2RL2-001	F2RL2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
F2RL2-001 ENSP00000296641 ENST00000296641	O00254 [Direct mapping] Proteinase-activated receptor 3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0009611 [response to wounding] GO:0015057 [thrombin receptor activity] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030168 [platelet activation] GO:0070493 [thrombin receptor signaling pathway] Show all	374 aa 42.5 kDa	Yes	7
F2RL2-002 ENSP00000426703 ENST00000504899	O00254 [Direct mapping] Proteinase-activated receptor 3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0009611 [response to wounding] GO:0015057 [thrombin receptor activity] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0070493 [thrombin receptor signaling pathway] Show all	352 aa 40.2 kDa	No	7