Expression of HCN1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Hyperpolarization activated cyclic nucleotide gated potassium channel 1

Protein class

Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA019195

GENE INFORMATION
Gene name	HCN1 (HGNC Symbol)
Synonyms	BCNG-1, BCNG1, HAC-2
Description	Hyperpolarization activated cyclic nucleotide gated potassium channel 1 (HGNC Symbol)
Entrez gene summary	The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
Chromosome	5
Cytoband	p12
Chromosome location (bp)	45254950 - 45696498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164588 (version 83.38)
Entrez gene	348980
UniProt	O60741 (UniProt - Evidence at protein level)
neXtProt	NX_O60741
Antibodypedia	HCN1 antibodies

PROTEIN BROWSER

HCN1-001	HCN1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HCN1-001 ENSP00000307342 ENST00000303230	O60741 [Direct mapping] Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Show all	Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030552 [cAMP binding] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0042802 [identical protein binding] GO:0045176 [apical protein localization] GO:0046549 [retinal cone cell development] GO:0055085 [transmembrane transport] GO:0071320 [cellular response to cAMP] GO:0071805 [potassium ion transmembrane transport] Show all	890 aa 98.8 kDa	No	5
HCN1-002 ENSP00000489134 ENST00000634658		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0055085 [transmembrane transport] Show all	295 aa 32.6 kDa	No	3