Tissue expression of HCN1 - Summary - The Human Protein Atlas

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HCN1

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	HCN1
Gene description	Hyperpolarization activated cyclic nucleotide gated potassium channel 1
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Tissue enhanced (cerebral cortex, cerebellum)
FANTOM5:	Group enriched (retina, brain, cerebellum, hippocampus, caudate, pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most CNS tissues.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA019195
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (retina, brain, cerebellum, hippocampus, caudate, pituitary gland)

GENE INFORMATION
Gene name	HCN1 (HGNC Symbol)
Synonyms	BCNG-1, BCNG1, HAC-2
Description	Hyperpolarization activated cyclic nucleotide gated potassium channel 1 (HGNC Symbol)
Entrez gene summary	The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
Chromosome	5
Cytoband	p12
Chromosome location (bp)	45254950 - 45696498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164588 (version 83.38)
Entrez gene	348980
UniProt	O60741 (UniProt - Evidence at protein level)
neXtProt	NX_O60741
Antibodypedia	HCN1 antibodies

PROTEIN BROWSER

HCN1-001	HCN1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HCN1-001 ENSP00000307342 ENST00000303230	O60741 [Direct mapping] Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Show all	Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030552 [cAMP binding] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0042802 [identical protein binding] GO:0045176 [apical protein localization] GO:0046549 [retinal cone cell development] GO:0055085 [transmembrane transport] GO:0071320 [cellular response to cAMP] GO:0071805 [potassium ion transmembrane transport] Show all	890 aa 98.8 kDa	No	5
HCN1-002 ENSP00000489134 ENST00000634658		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0055085 [transmembrane transport] Show all	295 aa 32.6 kDa	No	3

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.