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Hes-related family bHLH transcription factor with YRPW motif 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
B4DEI9 [Direct mapping] Hairy/enhancer-of-split-related with YRPW motif protein 1; cDNA FLJ52964, highly similar to Hairy/enhancer-of-split related with YRPW motif 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations
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GO:0003677 [DNA binding] GO:0006355 [regulation of transcription, DNA-templated]