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CTSB

GENERAL INFORMATION

Gene name

 CTSB

Gene description

 Cathepsin B

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 23
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA018156 , CAB000457
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CTSB

Synonyms

Description

 Cathepsin B (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 11842524 - 11869448

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164733 (version 83.38)

Entrez gene

 1508

UniProt

 P07858 (UniProt - Evidence at protein level)

neXtProt

 NX_P07858

Antibodypedia

 CTSB antibodies

PROTEIN BROWSER
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CTSB-001
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CTSB-005
CTSB-006
CTSB-007
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CTSB-014
CTSB-015
CTSB-016
CTSB-017
CTSB-018
CTSB-019
CTSB-020
CTSB-021
CTSB-023
CTSB-024
CTSB-025
CTSB-027
CTSB-030
CTSB-032
CTSB-033
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTSB-001
ENSP00000345672
ENST00000353047
P07858 [Direct mapping]
Cathepsin B Cathepsin B light chain Cathepsin B heavy chain
A0A024R374 [Target identity:100%; Query identity:100%]
Cathepsin B, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005901 [caveola]
GO:0006508 [proteolysis]
GO:0006914 [autophagy]
GO:0007283 [spermatogenesis]
GO:0007519 [skeletal muscle tissue development]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0009611 [response to wounding]
GO:0009612 [response to mechanical stimulus]
GO:0009749 [response to glucose]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0014070 [response to organic cyclic compound]
GO:0014075 [response to amine]
GO:0016324 [apical plasma membrane]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0030984 [kininogen binding]
GO:0032403 [protein complex binding]
GO:0034097 [response to cytokine]
GO:0036021 [endolysosome lumen]
GO:0042277 [peptide binding]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043394 [proteoglycan binding]
GO:0043434 [response to peptide hormone]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0045471 [response to ethanol]
GO:0046697 [decidualization]
GO:0046718 [viral entry into host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060548 [negative regulation of cell death]
GO:0070062 [extracellular exosome]
GO:0070670 [response to interleukin-4]
GO:0071260 [cellular response to mechanical stimulus]
GO:0097067 [cellular response to thyroid hormone stimulus]
Show all
 339 aa
37.8 kDa 		Yes 0
CTSB-002
ENSP00000432244
ENST00000533455
P07858 [Direct mapping]
Cathepsin B Cathepsin B light chain Cathepsin B heavy chain
A0A024R374 [Target identity:100%; Query identity:100%]
Cathepsin B, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0036021 [endolysosome lumen]
GO:0042470 [melanosome]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0097067 [cellular response to thyroid hormone stimulus]
Show all
 339 aa
37.8 kDa 		Yes 0
CTSB-003
ENSP00000435105
ENST00000530640
P07858 [Direct mapping]
Cathepsin B Cathepsin B light chain Cathepsin B heavy chain
A0A024R374 [Target identity:100%; Query identity:100%]
Cathepsin B, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0036021 [endolysosome lumen]
GO:0042470 [melanosome]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0097067 [cellular response to thyroid hormone stimulus]
Show all
 339 aa
37.8 kDa 		Yes 0
CTSB-004
ENSP00000433215
ENST00000531089
P07858 [Direct mapping]
Cathepsin B Cathepsin B light chain Cathepsin B heavy chain
A0A024R374 [Target identity:100%; Query identity:100%]
Cathepsin B, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0036021 [endolysosome lumen]
GO:0042470 [melanosome]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0097067 [cellular response to thyroid hormone stimulus]
Show all
 339 aa
37.8 kDa 		Yes 0
CTSB-005
ENSP00000434217
ENST00000534510
P07858 [Direct mapping]
Cathepsin B Cathepsin B light chain Cathepsin B heavy chain
A0A024R374 [Target identity:100%; Query identity:100%]
Cathepsin B, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0036021 [endolysosome lumen]
GO:0042470 [melanosome]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0097067 [cellular response to thyroid hormone stimulus]
Show all
 339 aa
37.8 kDa 		Yes 0
CTSB-006
ENSP00000409917
ENST00000453527
P07858 [Direct mapping]
Cathepsin B Cathepsin B light chain Cathepsin B heavy chain
A0A024R374 [Target identity:100%; Query identity:100%]
Cathepsin B, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0036021 [endolysosome lumen]
GO:0042470 [melanosome]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0097067 [cellular response to thyroid hormone stimulus]
Show all
 339 aa
37.8 kDa 		Yes 0
CTSB-007
ENSP00000342070
ENST00000345125
P07858 [Direct mapping]
Cathepsin B Cathepsin B light chain Cathepsin B heavy chain
A0A024R374 [Target identity:100%; Query identity:100%]
Cathepsin B, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0036021 [endolysosome lumen]
GO:0042470 [melanosome]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0097067 [cellular response to thyroid hormone stimulus]
Show all
 339 aa
37.8 kDa 		Yes 0
CTSB-013
ENSP00000435886
ENST00000531502
E9PS78 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0050790 [regulation of catalytic activity]
Show all
 92 aa
10.7 kDa 		Yes 0
CTSB-014
ENSP00000433379
ENST00000527215
E9PL32 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0050790 [regulation of catalytic activity]
Show all
 68 aa
7.8 kDa 		Yes 0
CTSB-015
ENSP00000436159
ENST00000534636
E9PQM1 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005730 [nucleolus]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050790 [regulation of catalytic activity]
Show all
 175 aa
19.5 kDa 		Yes 0
CTSB-016
ENSP00000436074
ENST00000524500
E9PR54 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0050790 [regulation of catalytic activity]
Show all
 98 aa
11.4 kDa 		Yes 0
CTSB-017
ENSP00000433995
ENST00000533572
E9PSG5 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005730 [nucleolus]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050790 [regulation of catalytic activity]
Show all
 170 aa
18.9 kDa 		Yes 0
CTSB-018
ENSP00000436122
ENST00000534149
E9PNL5 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005730 [nucleolus]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050790 [regulation of catalytic activity]
Show all
 143 aa
16.1 kDa 		Yes 0
CTSB-019
ENSP00000435074
ENST00000530296
E9PLY3 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005730 [nucleolus]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050790 [regulation of catalytic activity]
Show all
 165 aa
18.5 kDa 		Yes 0
CTSB-020
ENSP00000436627
ENST00000526195
E9PHZ5 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005730 [nucleolus]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050790 [regulation of catalytic activity]
Show all
 149 aa
16.6 kDa 		Yes 0
CTSB-021
ENSP00000434725
ENST00000527243
E9PNL5 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005730 [nucleolus]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050790 [regulation of catalytic activity]
Show all
 143 aa
16.1 kDa 		Yes 0
CTSB-023
ENSP00000435260
ENST00000534382
E9PKX0 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0050790 [regulation of catalytic activity]
Show all
 70 aa
8.1 kDa 		Yes 0
CTSB-024
ENSP00000432408
ENST00000532392
E9PR00 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 21 aa
2.4 kDa 		Yes 0
CTSB-025
ENSP00000432077
ENST00000524654
E9PID0 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 32 aa
3.7 kDa 		Yes 0
CTSB-027
ENSP00000431518
ENST00000526645
E9PKQ7 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005730 [nucleolus]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050790 [regulation of catalytic activity]
Show all
 136 aa
15.4 kDa 		Yes 0
CTSB-030
ENSP00000431143
ENST00000532656
E9PKX0 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0050790 [regulation of catalytic activity]
Show all
 70 aa
8.1 kDa 		Yes 0
CTSB-032
ENSP00000433929
ENST00000528965
E9PIS1 [Direct mapping]
Cathepsin B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0050790 [regulation of catalytic activity]
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 55 aa
6.5 kDa 		Yes 0
CTSB-033
ENSP00000435650
ENST00000505496
E9PJ67 [Direct mapping]
Cathepsin B
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0050790 [regulation of catalytic activity]
Show all
 101 aa
11.8 kDa 		Yes 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.