Cell atlas - DEFB1 - The Human Protein Atlas

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DEFB1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	DEFB1
Gene description	Defensin, beta 1
Protein class	Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (THP-1, SCLC-21H, NB-4)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (THP-1, SCLC-21H, NB-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	DEFB1 (HGNC Symbol)
Synonyms	BD1, DEFB-1, DEFB101, HBD-1, HBD1, MGC51822
Description	Defensin, beta 1 (HGNC Symbol)
Entrez gene summary	Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p23.1
Chromosome location (bp)	6870575 - 6878022
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164825 (version 83.38)
Entrez gene	1672
UniProt	P60022 (UniProt - Evidence at protein level)
neXtProt	NX_P60022
Antibodypedia	DEFB1 antibodies

PROTEIN BROWSER

DEFB1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEFB1-001 ENSP00000297439 ENST00000297439	P60022 [Direct mapping] Beta-defensin 1 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002227 [innate immune response in mucosa] GO:0002526 [acute inflammatory response] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0006935 [chemotaxis] GO:0006952 [defense response] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009617 [response to bacterium] GO:0019731 [antibacterial humoral response] GO:0033574 [response to testosterone] GO:0045087 [innate immune response] GO:0050830 [defense response to Gram-positive bacterium] GO:0070062 [extracellular exosome] Show all	68 aa 7.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.