Tissue expression of DEFB1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DEFB1
Gene description	Defensin, beta 1
Protein class	Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (kidney, cervix, uterine)
GTEx:	Group enriched (salivary gland, kidney, pancreas)
FANTOM5:	Group enriched (pancreas, kidney, salivary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney, cervix, uterine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (salivary gland, kidney, pancreas)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pancreas, kidney, salivary gland)

GENE INFORMATION
Gene name	DEFB1 (HGNC Symbol)
Synonyms	BD1, DEFB-1, DEFB101, HBD-1, HBD1, MGC51822
Description	Defensin, beta 1 (HGNC Symbol)
Entrez gene summary	Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p23.1
Chromosome location (bp)	6870575 - 6878022
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164825 (version 83.38)
Entrez gene	1672
UniProt	P60022 (UniProt - Evidence at protein level)
neXtProt	NX_P60022
Antibodypedia	DEFB1 antibodies

PROTEIN BROWSER

DEFB1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEFB1-001 ENSP00000297439 ENST00000297439	P60022 [Direct mapping] Beta-defensin 1 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002227 [innate immune response in mucosa] GO:0002526 [acute inflammatory response] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0006935 [chemotaxis] GO:0006952 [defense response] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009617 [response to bacterium] GO:0019731 [antibacterial humoral response] GO:0033574 [response to testosterone] GO:0045087 [innate immune response] GO:0050830 [defense response to Gram-positive bacterium] GO:0070062 [extracellular exosome] Show all	68 aa 7.4 kDa	Yes	0