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Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Enzymes ENZYME proteins Oxidoreductases SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0001525 [angiogenesis] GO:0001542 [ovulation from ovarian follicle] GO:0001701 [in utero embryonic development] GO:0001974 [blood vessel remodeling] GO:0002028 [regulation of sodium ion transport] GO:0003057 [regulation of the force of heart contraction by chemical signal] GO:0003100 [regulation of systemic arterial blood pressure by endothelin] GO:0003785 [actin monomer binding] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004517 [nitric-oxide synthase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006527 [arginine catabolic process] GO:0006809 [nitric oxide biosynthetic process] GO:0007005 [mitochondrion organization] GO:0007263 [nitric oxide mediated signal transduction] GO:0007596 [blood coagulation] GO:0008217 [regulation of blood pressure] GO:0008285 [negative regulation of cell proliferation] GO:0009408 [response to heat] GO:0010181 [FMN binding] GO:0010544 [negative regulation of platelet activation] GO:0014740 [negative regulation of muscle hyperplasia] GO:0014806 [smooth muscle hyperplasia] GO:0016491 [oxidoreductase activity] GO:0019430 [removal of superoxide radicals] GO:0020037 [heme binding] GO:0030324 [lung development] GO:0030666 [endocytic vesicle membrane] GO:0031284 [positive regulation of guanylate cyclase activity] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0034405 [response to fluid shear stress] GO:0034617 [tetrahydrobiopterin binding] GO:0034618 [arginine binding] GO:0043267 [negative regulation of potassium ion transport] GO:0043542 [endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045766 [positive regulation of angiogenesis] GO:0045776 [negative regulation of blood pressure] GO:0045909 [positive regulation of vasodilation] GO:0046209 [nitric oxide metabolic process] GO:0046870 [cadmium ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0050880 [regulation of blood vessel size] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051346 [negative regulation of hydrolase activity] GO:0051926 [negative regulation of calcium ion transport] GO:0055114 [oxidation-reduction process] GO:0090382 [phagosome maturation] GO:0097110 [scaffold protein binding] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)