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PSIP1

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GENERAL INFORMATION

Gene name

 PSIP1

Gene description

 PC4 and SFRS1 interacting protein 1

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA019697
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA019697 A-431 Nucleoplasm
HPA019697 U-2 OS Nucleoplasm
HPA019697 U-251 MG Nucleoplasm

siRNA VALIDATION
 

Relative fluorescence intensity (RFI)

Antibody

 HPA019697

siRNA validation

 Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

 34%

p-value

 < 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA019697 siRNA 1 U-2 OS
HPA019697 scrambled U-2 OS

GENE INFORMATION

Gene name

 PSIP1 (HGNC Symbol)

Synonyms

 LEDGF, p52, p75, PSIP2

Description

 PC4 and SFRS1 interacting protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 p22.3

Chromosome location (bp)

 15464066 - 15511019

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164985 (version 83.38)

Entrez gene

 11168

UniProt

 O75475 (UniProt - Evidence at protein level)

neXtProt

 NX_O75475

Antibodypedia

 PSIP1 antibodies

PROTEIN BROWSER
PSIP1-003
PSIP1-004
PSIP1-005
PSIP1-006
PSIP1-007
PSIP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSIP1-003
ENSP00000370109
ENST00000380733
O75475 [Direct mapping]
PC4 and SFRS1-interacting protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000395 [mRNA 5'-splice site recognition]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006979 [response to oxidative stress]
GO:0009408 [response to heat]
GO:0016032 [viral process]
GO:0033613 [activating transcription factor binding]
GO:0034399 [nuclear periphery]
GO:0035327 [transcriptionally active chromatin]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0075713 [establishment of integrated proviral latency]
GO:0097100 [supercoiled DNA binding]
Show all
 530 aa
60.1 kDa 		No 0
PSIP1-004
ENSP00000370114
ENST00000380738
O75475 [Direct mapping]
PC4 and SFRS1-interacting protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000395 [mRNA 5'-splice site recognition]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006979 [response to oxidative stress]
GO:0009408 [response to heat]
GO:0016032 [viral process]
GO:0033613 [activating transcription factor binding]
GO:0034399 [nuclear periphery]
GO:0035327 [transcriptionally active chromatin]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0075713 [establishment of integrated proviral latency]
GO:0097100 [supercoiled DNA binding]
Show all
 530 aa
60.1 kDa 		No 0
PSIP1-005
ENSP00000477077
ENST00000481862
V9GYT7 [Direct mapping]
PC4 and SFRS1-interacting protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 65 aa
7.8 kDa 		No 0
PSIP1-006
ENSP00000370091
ENST00000380715
O75475 [Direct mapping]
PC4 and SFRS1-interacting protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000395 [mRNA 5'-splice site recognition]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006979 [response to oxidative stress]
GO:0009408 [response to heat]
GO:0016032 [viral process]
GO:0033613 [activating transcription factor binding]
GO:0034399 [nuclear periphery]
GO:0035327 [transcriptionally active chromatin]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0075713 [establishment of integrated proviral latency]
GO:0097100 [supercoiled DNA binding]
Show all
 329 aa
37.3 kDa 		No 0
PSIP1-007
ENSP00000370092
ENST00000380716
O75475 [Direct mapping]
PC4 and SFRS1-interacting protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000395 [mRNA 5'-splice site recognition]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006979 [response to oxidative stress]
GO:0009408 [response to heat]
GO:0016032 [viral process]
GO:0033613 [activating transcription factor binding]
GO:0034399 [nuclear periphery]
GO:0035327 [transcriptionally active chromatin]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0075713 [establishment of integrated proviral latency]
GO:0097100 [supercoiled DNA binding]
Show all
 333 aa
37.7 kDa 		No 0
PSIP1-201
ENSP00000380653
ENST00000397519
O75475 [Direct mapping]
PC4 and SFRS1-interacting protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000395 [mRNA 5'-splice site recognition]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006979 [response to oxidative stress]
GO:0009408 [response to heat]
GO:0016032 [viral process]
GO:0033613 [activating transcription factor binding]
GO:0034399 [nuclear periphery]
GO:0035327 [transcriptionally active chromatin]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0075713 [establishment of integrated proviral latency]
GO:0097100 [supercoiled DNA binding]
Show all
 333 aa
37.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.