Expression of NKX6-3 in cancer - Summary

CANCER ATLAS

Gene description

NK6 homeobox 3

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042790

GENE INFORMATION
Gene name	NKX6-3 (HGNC Symbol)
Synonyms	FLJ25169
Description	NK6 homeobox 3 (HGNC Symbol)
Entrez gene summary	The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	41645178 - 41650669
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000165066 (version 83.38)
Entrez gene	157848
UniProt	A6NJ46 (UniProt - Evidence at transcript level)
neXtProt	NX_A6NJ46
Antibodypedia	NKX6-3 antibodies

PROTEIN BROWSER

NKX6-3-001	NKX6-3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NKX6-3-001 ENSP00000428361 ENST00000518699	A6NJ46 [Direct mapping] Homeobox protein Nkx-6.3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	265 aa 28.9 kDa	No	0
NKX6-3-002 ENSP00000429553 ENST00000524115	A6NJ46 [Direct mapping] Homeobox protein Nkx-6.3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001709 [cell fate determination] GO:0002067 [glandular epithelial cell differentiation] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030857 [negative regulation of epithelial cell differentiation] GO:0043565 [sequence-specific DNA binding] Show all	135 aa 14.3 kDa	No	0